Prof. Dr. Ralf Brandes
Institute of Cardiovascular Physiology
Faculty of Medicine
Goethe University Frankfurt
Theodor-Stern-Kai 7| 60590 Frankfurt am Main
Prof. Dr. David Leistner
Medical Clinic III, Cardiology/Angiology
Faculty of Medicine
Goethe University Frankfurt
Theodor-Stern-Kai 7| 60590 Frankfurt am Main
Endothelial damage in erosion-induced myocardial ischemia
Plaque erosion is a major cause of myocardial ischaemia. It is unclear why damage to the endothelium, and thus erosion, occurs, and this will be investigated in the project. Endothelial cells in culture and in vivo will be exposed to different flow and environmental conditions and their damage will be described. In patients, photon-counting coronary computed tomography and flow reconstruction will be used to calculate endothelial stress and determine the consequences for endothelial cell activation.