Prof. Dr. Stefanie Dimmeler
Institute for Cardiovascular Regeneration
Faculty of Medicine
Goethe University Frankfurt
Theodor-Stern-Kai 7| 60590 Frankfurt am Main
Endothelial plasticity and damage control
Project B01 explores how endothelial cells (ECs) drive inflammation and remodeling after myocardial infarction (MI). It will examine how infarct-associated ECs perpetuate immune activation, how senescent ECs amplify chronic inflammation and impair repair, and how ischemic injury imprints lasting epigenetic “memory” on ECs. By uncovering these mechanisms, the work aims to reveal new therapeutic targets to limit inflammaging and improve cardiac recovery after ischemia.