Project A05

Endothelial cell microproteins (miPs) exhibit altered expression and release in response to damage and may influence cardiovascular disease progression. However, their functions remain largely uncharacterized. This project will characterize two intracellular endothelial miPs through functional analyses and multi-omic approaches. We will also investigate a circulating miP whose abundance was increased in patients with hypertension and heart failure with reduced ejection fraction to determine effects on endothelial and vascular smooth muscle cells as well as potential roles in regulat-ing vascular and cardiac function.