Prof. Dr. Florian Leuschner
Universitätsklinikum Heidelberg
Im Neuenheimer Feld 410 | 69120 Heidelberg
Type 2 immunity in cardiac injury and fibrosis
Project B07 investigates how Type 2 immune pathways orchestrate cardiac repair after myocardial infarction (MI). We will dissect calcium-dependent mast cell signalling and its impact on immune-stromal communication, map Type 2 immune niches using spatial multi-omics, and assess how hypercholesterolemia perturbs reparative immunity. Combining advanced MI models with integrated multi-omics and patient analyses, the project seeks to establish a mechanistic framework for Type 2 immune regulation and identify novel therapeutic strategies to enhance cardiac repair