Prof. Dr. Ivan Đikić

Institute for Biochemistry II
Faculty of Medicine
Goethe University Frankfurt
Theodor-Stern-Kai 7| 60590 Frankfurt am Main

Prof. Dr. Michael Potente

Berlin Institute of Health (BIH) and
Max-Delbrück Center for Molecular Medicine
Lindenberger Weg 80 | 13125 Berlin

Vascular damage control by deubiquitinases

Endothelial cells (ECs) are long-lived cells that rely on conserved stress response pathways to preserve cellular integrity in adverse environmental conditions. These pathways are particularly important during tissue revascularization, where ECs encounter diverse stresses such as nutrient and oxygen deprivation. But how ECs surveil, adapt to and shut off stress signalling is poorly understood. Here we will study the role of deubiquitinases (DUBs) in these processes focussing on models of tissue hypoxia and ischemia. We hypothesize that DUBs are essential components of stress-induced signalling networks, which cooperatively protect ECs against acute damage.