Dr. Mauro Siragusa
Institute for Vascular Signalling
Faculty of Medicine
Goethe University
Theodor-Stern-Kai 7 | 60590 Frankfurt am Main
Microprotein-mediated responses to vascular damage
We have established a proteo-genomic pipeline to identify microproteins (miPs; aa <100) in endothelial cells under homeostatic conditions as well as changes in miP expression that accompany endothelial cell activation and damage in vitro and in vivo. In this project we plan to unravel the function of 8 damage-regulated endothelial miPs and to determine how they influence endothelial cell function and crosstalk between endothelial cells and other cells in the stroma-vascular compartment. We will also elucidate changes in miP expression following myocardial infarction in mice and in samples from patients with coronary artery disease and acute myocardial infarction.