Prof. Dr. Michael Potente
Berlin Institute of Health (BIH) and
Max-Delbrück Center for Molecular Medicine
Käthe-Beutler-Haus
Lindenberger Weg 80 | 13125 Berlin
Metabolic surveillance of ischaemic damage responses
While studying stress-adaptive mechanisms in the previous funding period, we unexpectedly identified an evolutionarily ancient nutrient-sensing pathway at the core of artery formation. Given its developmental essentiality, we propose that this pathway also drives the formation of new arterial connections during acute ischaemia to counteract further damage. Conversely, obesity- and age-related metabolic disturbances may perturb this regulatory circuit and thereby promote arteriopathies and tissue damage.