Project A03

Project A03 studies the relevance of the glutaminase II pathway in the damage response. We will determine the function of kynurenine aminotransferases (KYATs) in choroidal neovascularization, myocardial infarction and neointima formation. Moreover, we will investigate the endothelial func-tion of NIT2-derived αKG as co-factor for epigenetic and oxygen sensing enzymes under basal and inflammaging conditions. We will also establish a metabolic link between NIT2 and adenine levels in endothelial cells.