Project A04

Project A04 investigates how altered GPCR signalling affects cardiovascular cell populations after acute mechanical or ischemic damage. Specifically, we will address the role of two neuropeptide GPCR ligands – neurotensin and neuromedin B – in cardiac remodelling and will determine how specific receptor agonists or antagonists alter cardiac damage responses. Furthermore, we will study the mechanisms underlying damage-induced adaptation of GPCR expression and explore how pharmacological inhibition of orphan receptor dimerization affects cardiac remodelling.