Prof. Dr. Dr. Thomas Braun
Max Planck Institute for Heart and Lung Research
Dept. Cardiac Development and Remodelling
Ludwigstraße 43 | 61231 Bad Nauheim
PD Dr. Jochen Pöling
Max Planck Institute for Heart and Lung Research
Dept. Cardiac Development and Remodelling
Ludwigstraße 43 | 61231 Bad Nauheim
Control of innate immune cell trafficking and clearance by REG proteins in the diseased heart
Project B08 examines how REG proteins regulate innate immune maturation, interorgan signalling, and tissue remodelling in cardiovascular disease, focusing on the cardiac-pancreatic axis of REG induction, HEXA/HEXB-dependent myeloid maturation, and REG-mediated neutrophil clearance. Additional emphasis is placed on REG4-driven macrophage-associated infarct repair and on how Reg deficiency promotes immune imbalance, pathological lym-phangiogenesis, and atherosclerosis.