Prof. Dr. Dr. Thomas Braun
Max Planck Institute for Heart and Lung Research
Dept. Cardiac Development and Remodelling
Ludwigstraße 43 | 61231 Bad Nauheim
PD Dr. Jochen Pöling
Max Planck Institute for Heart and Lung Research
Dept. Cardiac Development and Remodelling
Ludwigstraße 43 | 61231 Bad Nauheim
Control of innate immune cell trafficking and clearance by REG proteins in the diseased heart
The function of different immunomodulatory REG proteins in the control of macrophage trafficking and neutrophil clearance in the diseased heart after acute myocardial infarction will be explored. It will be determined whether REG3γ and REG4 eliminate different subsets of neutrophils compared to REG3β, or serve different purposes. The effects of conditional inactivation of Reg3g, Reg4 and the Reg gene cluster will be analyzed in single and compound mouse mutants as well as in neonatal and adult hearts. Finally, it will be determined whether reprogramming of cardiomyocytes to a regeneration-competent state has an impact on immune cells and rewinds the cardio-immunological network.