Prof. Dr. Amparo Acker-Palmer

Institute of Cell Biology and Neuroscience
BMLS
Goethe University Frankfurt
Max-von-Laue-Str. 15| 60438 Frankfurt am Main

Dr. Marta Segarra

Institute of Cell Biology and Neuroscience
BMLS
Goethe University Frankfurt
Max-von-Laue-Str. 15| 60438 Frankfurt am Main

Neurovascular signals controlling CNS barrier homeostasis in response to damage

The vasculature in the central nervous system (CNS) ensures the selective transport of blood-borne substances to the brain parenchyma through the so-called blood-CNS barriers. Following damage, the tightness of the barrier is decreased, adversely affecting neuronal function. We will investigate the role of Fibronectin Leucine-rich Repeat Transmembrane (FLRT) protein signalling in mechanisms of revascularisation and barrier repair in disease models of retinopathies and stroke.